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A migraine is characterized by recurrent headaches that may be moderate to severe. They usually effect one side of the head and tend to be pulsating in nature and last from a few hours to 3 days. Associated symptoms may include nausea, vomiting and light sound or smell sensitivity. One third may have an aura which precedes the migraine. Onset may start as early as puberty. Causes may include environmental stimuli and genetics (15% worldwide). Risk factors include family history (genetics) and being female (3 times more prevalent). Preventative treatment (pharmacological) includes metoprolol, valproate and topiramate. Treatment includes ibuprofen, triptans and ergotamines. The underlying mechanisms are not completely known, however it appears that the mediator is small protein called CGRP (calcitonin gene-related peptide). It is highly prevalent in the sensory nerves that supply the head and the neck and is involved in pain transmission as well as being a very potent vasodilator (may be part of the pathology). The big question is, and knowing that CGRP seems to be involved at the outset, are there other (more natural/less onerous options)? The following papers identify interventions that directly/indirectly address CGRP.

  1. Endocannabinoids in Chronic Migraine: CSF findings suggest a system failure. Neuropsychopharmacology. The endocannabionoid system responds to CBD (in this case I use ONEcbd) and an endocannabionid that is natural to the body (PEA-palmitoylethanolamide)

  2. 2. Tolerability of Palmitoylethanolamide (PEA)in a Pediatric Population Suffering from Migraine:A pilot study. Pain Research and Management.

  3. The Preventive Treatment of Migraine with Low Dose Naltrexone(LDN)/Acetaminophen Combination: Findings of a Small, Randomized Double Blind, and Placebo-Controlled Clinical Trial with an Open Label Extension for None-Responders.

  4. Herbal supplements that impact CGRP include Sangre de Grado (Dragons blood) and grape pomace.

In summary, and ignoring all of the science, ONEcbd,PEA and the herbal supplements have an important role in treating migraine.

Updated: Nov 11, 2021

More and more of my patients are becoming familiar with the term methylation. This is usually secondary to someone running an abreviated genetics test looking at the 3 most common methylation mutations; comt, 1298 and 677, looking for a reason that may be causing depression, etc. Why is methylation important? Methylation is required for:

  1. energy (CoQ10, carnitine, creatine and atp via the krebs cycle.

  2. Bile production

  3. Nerves (myelination (insulates the nerves)

  4. Building and maintaining cell membranes

  5. Generating and degrading neurotransmitters (serotonin, dopamine, norepinephrine and epinephrine.

  6. Generating purines for new DNA and RNA

  7. Generating SAMe (depression)

  8. Performing Phase II liver conjugation of heavy metals, hydroxyestradiols, norepi, epi, histamine, etc.

  9. Neurological healing

  10. Addressing inflammation

  11. Memory

  12. Sleep

7 signs you may need methylation support: (Methylfolate and methyl B12/Methyl B complex by Ortho)

  1. brain fog after eating

  2. Redfaced after excercising

  3. Low energy

  4. MTHFR mutation or high homocysteine

  5. Stress

  6. Increased estrogen

  7. Trouble falling asleep.

  8. Genetic predisposition which can be triggered by live viral vaccines, severe infections, environmental toxins, dietary, allergies, trauma, surgery, emotional and growth

  9. Depression; An article from the American Journal of Psychiatry ran a double blind study (the best)

  10. Other risk factors include; Elderly, vegetarians, GI disorders, bariatric surgery patients, eating disorders, Pregnant women with hyperemesis

  11. Depression: Many of my patients present with depression and are frequently on psychotropics (antidepressants). We live in a high stress environment and combined with daily stressors no surprise. The other cause (very common, i.e. up to 70% of people have an MTHFR homozygous mutation (thanks mom and dad) is genetics. (There is a wonderful genetics test looking at all potential mutations not just methylation). A study in the American Journal of psychiatry concluded that, L-methylfolate (in Methyl B complex by Ortho) "may constitute an effective, safe, and well tolerated treatment strategy for patients with major depressive disorder who have a partial or no response to SSRIs."

What is PEA?

PEA is an endogenous (manufactured by the body) endocannabinoid (very similar to CBD and can be used on conjunction). It is a fatty acid amide and found in many foods. Nobel prize winner Levi-Montalcini identified PEA as a naturally occurring molecule, describing its value in treating chronic infections and pain. Following its discovery hundreds of scientific studies have been carried out to show that it is very effective and safe to use (no side effects and no drug interactions (unlike CBD).

What does PEA do in our body?

PEA, while natural to the body, frequently does not meet the body's needs when presented with chronic pain, inflammation, depression/anxiety, etc. Supplementing the body's shortage can have a significant, positive impsct opn the above mentioned pathologies. Like CBD, PEA is an agonist (stimulates) very specific receptors that mediate pain and inflammation.

Specific conditions with evidence of benefits of PEA

  1. Neuroinflammation (neuropathic pain)

  2. Fibromyalgia

  3. Muscular cramps (night time cramping)

  4. Traumatic brain injury

  5. Mast cell activation syndrome

  6. Anxiety and depression

  7. Rheumatoid arthritis

  8. Colds/flu

  9. Ostoarthritis

  10. Chronic regional pain syndrome (CRPS)

  11. Back pain

  12. Endometriosis

  13. Multiple sclerosis

  14. Migraines

  15. Parkinsons

  16. Vulvadynia

  17. Chemo induced neuropathy

  18. Decrease blood pressure

How do I take PEA?

The PEA That I recommend comes in powder form. Each scoop (scoop provided) is 600mg. Most of the clinical studies suggewst 600mg 1 to 2 times a day. Each dose can be mixed with food of choice (no taste and the fattier the food the better) or preferably mix the dose with a teaspoon of oil (coconut, olive, mct oil (medium chain triglyceride ), avacado, fish, etc. This enhances absorption and increases blood levels.

For additional supplement information contact Amy Ferris 940-372-4596

$45.00 for 36 grams (once daily dosing=60 days.)

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