More on Drug Interactions

December 21, 2019

In my practice, as a functional medicine clinician, I prescribe quite a bit of CBD for a myriad of pathologies. I do not, however, allow any of my clients to begin using CBD until I have reviewed their medication profiles for drug interactions.   The importance of doing this can’t be over stated as the potential for severe side effects is quite high.   The liver has 2 detox phases. Phase I (cytochrome p450 enzymes system) is where basically the majority of all drugs (60% or more) are metabolized via the cyp450 system, including CBD (specifically, cyp3a4, 3a5, ea7, cyp 2c9, 2c19 and cyp2d6.  And phase II where the metabolites from Phase I are further metabolized and eliminated.  The balance is critical between the 2 but a discussion for another time. So how does CBD via the cyp450 system interact with drugs to create a drug interaction?   Quite simply, CBD competitively inhibits the cyp450 enzymes thus decreasing the metabolism of the drug resulting in increased blood levels with the potential to enhance associated side effects.  A perfect example would be Prozac (see website for a blog addressing this interaction with a client) and other psychotropics all of which have the potential for serious side effects. 

 

I have a number of clients come to me to either to help them get off the drugs they are on, or to minimize the number.  I have a lot of ways addressing this, but CBD is on the top of my list. An obvious example would be pain management. CBD, in conjunction with palmotylethanolamine (PEA) works on a totally different pain receptor (different blog).   The list is extensive in terms of what I have had success with, in replacing or minimizing the use of allopathic medicine.   It includes, cancer, inflammation, depression/anxiety, BP medications, diabetes, dermatology, etc.  I need to point out however, removing or minimizing the use of drugs can be a lengthy process (weeks to months in some cases) that involves balancing the dosing of CBD with the lowering of a particular drug especially the psychotropics, drugs used for autoimmunity, blood pressure meds etc. to avoid an exacerbation of symptoms.  In terms of blood pressure meds, I use the drug interaction.   The initial increase in the effectiveness of the BP med when combined with CBD frequently begins to lower the blood pressure allowing us to decrease the dose, or in the case of multiple BP meds, begin to eliminate one.

Please reload

Recent Post

September 1, 2020

Cells have 3 membranes: 1. the cell wall that defines cellular structure and maintains integrity 2. the mitochondrial membrane that support the cell'...

August 28, 2020

How do you get candida overgrowth?  A healthy microbiome (gut bacteria) typically can keep your candida levels in check, however,several factors can...

December 21, 2019

In my practice, as a functional medicine clinician, I prescribe quite a bit of CBD for a myriad of pathologies. I do not, however, allow any of my cl...

May 27, 2019

I get asked alot about aging.   Aging is inevitable.   How quickly we age is based on a number of factors.  Genetics (all about triggers), stress, di...

May 8, 2019

Excessive weight loss is epidemic in this country.  Once estrogen dominance, adrenal stress (cortisol) and hypothyroidism have been ruled out what is...

January 2, 2019

When prescribing or purchasing CBD, in any form, it is very important that a medication profile be reviewed and checked for potential drug interactio...

November 17, 2018

It is amazing to me that with all my education I had never heard about the endocannabinoid system.  This goes also, for my nurse and physician collea...

June 25, 2018

We all know that an appropriate weight is critical for overall health.  Despite that, achieving a healthy weight can be extremely difficult (having s...

June 20, 2018

The thyroid gland plays a major role in the metabolism (converting food to energy), growth and development of the human body and is part of the endoc...

Please reload

©2018 ASK DR. RICK | All Rights Reserved.